A new dimension for Brain-on-chip design

We empower scientists to venture into the unknown

Discovering functional biomarkers for brain organoids

CorePlate™ 3D heralds in a new era of exploration

Standard MEA

Low resolution

CorePlate™ 2D

High resolution

CorePlate™ 3D

High resolution in 3D

Increased complexity and data depths

Our challenge? The future!

3Brain builds technology to face life’s complexity head-on

High-definition BioSPU core

Electrodes mounted on coated pillars

First 3D CMOS-chip
4,096 gold-coated sensory electrodes
Bio-compatible polymer isolation
Microfluidic channels
Bidirectional cell-electronic interface
On-chip signal processing

Get the full picture

CorePlate™ 3D , because planet earth is not flat either

Current flat technologies cannot measure the majority of neurons in a tissue or organoid.
Our first-in-class chip design comes with unique potential:

Measurement supremacy

Reproducible probing of cytoarchitecture,
label-free deep access to biologically relevant cells.

Integrated microfluidics

Increased cell viability,
Flawless compound delivery.

Retain tissue integrity

Easy, non-destructive anchoring,
multiple uses, quick turnover.

Measurement supremacy

Reproducible probing of cytoarchitecture, label-free deep accessto biologically relevant neurons.

Integrated Microfluidics

Increased cell viability,Flawless compound delivery.

Retain tissue integrity

Easy, non-destructive anchoring, multiple uses, quick turnover.

Show, don’t tell

CorePlate™ 3D was developed with and for neuroscientists

Activity footprint of 3D organoids & tissues through the Accura 3D technology - Image courtesy of: a:head bio AG and University of Pavia

Activity footprint of 3D organoids & tissues.

Image courtesy of: a:head bio AG and University of Pavia

Explore in vitro organoids & ex vivo brain slices

CorePlate™ 1W -3D 38/60/90 enables the investigation of 3D cellular networks at unprecedented depths and resolution. Our real-time biosignal processing microchip broadens the concept of label-free functional imaging beyond optical approaches.

Our bidirectional pixel array technology empowers researchers to communicate with cells directly through targeted sending and reading of biosignals. Compared to other cell-electronic interfaces, CorePlate™ 1W -3D 38/60/90 has many unique advantages: