A new dimension for Brain-on-chip design

We empower scientists to venture into the unknown
3Brain's Accura 3D Tech

Discovering functional biomarkers for brain organoids

CorePlate™ 3D  heralds in a new era of exploration

Standard MEA

Standard MEA in low resolution

Low resolution

CorePlate™ 2D

Accura 2D tech in high resolution

High resolution

CorePlate™ 3D

Accura 3D tech in high resolution

High resolution in 3D

Increased complexity and data depths

Our challenge? The future!

3Brain builds technology to face life’s complexity head-on

High-definition BioSPU core of 3Brain's Accura 3D tech

High-definition BioSPU core

Electrodes mounted on coated pillars of 3Brain's Accura 3D tech

Electrodes mounted on coated pillars

  • First 3D CMOS-chip

  • 4,096 gold-coated sensory electrodes

  • Bio-compatible polymer isolation

  • Microfluidic channels

  • Bidirectional cell-electronic interface

  • On-chip signal processing

Get the full picture

CorePlate™ 3D , because planet earth is not flat either

Current flat technologies cannot measure the majority of neurons in a tissue or organoid.
Our first-in-class chip design comes with unique potential:

Accura 3D - Measurement supremacyAccura 3D - Integrated microfluidicsAccura 3D - retain tissue integrity

Measurement supremacy

Reproducible probing of cytoarchitecture,
label-free deep access to biologically relevant cells.

Integrated microfluidics

Increased cell viability,
Flawless compound delivery.

Retain tissue integrity

Easy, non-destructive anchoring,
multiple uses, quick turnover.

Accura 3D - Measurement supremacy

Measurement supremacy

Reproducible probing of cytoarchitecture,  label-free deep accessto biologically relevant neurons.

Accura 3D - Integrated microfluidics

Integrated Microfluidics

Increased cell viability,Flawless compound delivery.

Accura 3D - retain tissue integrity

Retain tissue integrity

Easy, non-destructive anchoring, multiple uses, quick turnover.

Show, don’t tell

CorePlate™ 3D was developed with and for neuroscientists

Activity footprint of 3D organoids & tissues through the Accura 3D technology - Image courtesy of: a:head bio AG and University of PaviaActivity footprint of 3D organoids & tissues through the Accura 3D technology - Image courtesy of: a:head bio AG and University of Pavia
Activity footprint of 3D organoids & tissues through the Accura 3D technology - Image courtesy of: a:head bio AG and University of PaviaActivity footprint of 3D organoids & tissues through the Accura 3D technology - Image courtesy of: a:head bio AG and University of Pavia

Activity footprint of 3D organoids & tissues.

Image courtesy of: a:head bio AG and University of Pavia

Explore in vitro organoids & ex vivo brain slices

CorePlate™ 1W -3D 38/60/90 enables the investigation of 3D cellular networks at unprecedented depths and resolution. Our real-time biosignal processing microchip broadens the concept of label-free functional imaging beyond optical approaches.

Our bidirectional pixel array technology empowers researchers to communicate with cells directly through targeted sending and reading of biosignals. Compared to other cell-electronic interfaces, CorePlate™ 1W -3D 38/60/90 has many unique advantages:

  • More signal than flat technologies

  • Increased robustness and sensitivity

  • Preserves tissue integrity

  • New mechanistic insights and phenotypes

  • Drug screening and biomarker discovery

  • Gain unrivaled access to the complexities of biological systems

Any questions? Book a chat or email us, as our neuroscientist team is here to assist you.
Contact Us

CorePlate™ 3D and brain organoids

Activity map superimposed to the image of the organoid mounted on the 3D chip. Image courtesy of: a:head bio AG

>20x

Sensed
Cells

Activity map superimposed to the image of the organoid mounted on the 3D chip. Image courtesy of: a:head bio AG

Activity map superimposed to the image of the organoid mounted on the 3D chip.

Image courtesy of: a:head bio AG

Hypercharge into new discoveries

  • 3D chip captures 20-50x more signal than flat technologies

  • Increase the robustness and sensitivity of your recording

  • Discover hitherto unknown connectivity and network dynamics

  • Allows for phenotypic screening and biomarker discovery

  • Non-destructive to cytoarchitecture

CorePlate™  2D vs. 3D microchip on brain tissue slices

Brain slices 2D recording

Cerebellar slice 2D recording
Cerebellar slice 3D recordingCerebellar slice 3D recording

Brain slices 3D recording

Cerebellar slice 3D recording
Cerebellar slice 2D recordingCerebellar slice 2D recording
Accura-3D vs. 2D microchip on brain tissue slices

Embrace the most nuanced inside view

  • Record more cells and signals

  • Bypass damaged cell surface layers of tissue slices

  • Increase the robustness of your measurements

  • Better reproducibility

Accura-3D vs. 2D microchip on brain tissue slices

On chip microfluidic channels for 3D model systems

on chip microfluidic channelsCell viability - On chip microfluidic channels for 3D model systems

Response to sodium-channel blocker TTX

Response to sodium-channel blocker TTX - On chip microfluidic channels for 3D model systems

Developed for drug and phenotype screening

  • Free nutrient and oxygen flow from below

  • Increased cell viability and health

  • Retains tissue integrity

  • Efficient and easy compound delivery

Do you want to know more?
Book a chat or email us, as our neuroscientist team is here to assist you.
Contact Us