Single-Well HD-MEAs

High-density microelectrode arrays with large sensing areas

Our high-density microelectrode array (HD-MEA), also known as multielectrode array, features 4,096 low-noise microelectrodes that allow for simultaneous electrophysiological recording.

3Brain's Single-well high-density microelectrode arrays features 4,096 low-noise microelectrodes that allow for simultaneous electrophysiological recording.

Overview

The perfect tool for your brain research

Investigating cellular networks requires time, expertise and effort to obtain the performance necessary to validate research hypotheses. With 3Brain as your technology partner, you can easily capture every cell signal in high resolution.
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Our powerful CMOS MEA (microelectrode array / multielectrode array) system collects high-density electrophysiological data from preparations made of brain slices, neuronal tissue, human-derived stem cells,brain organoids, retinal tissue and cardiac cultures and tissues.

Different HD-MEA chip models for our microelectrode arrays are available to match your experimental needs in terms of resolution, field of view and stimulation capabilities.
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Electrodes are coated with platinum to provide a stable and fully biocompatible surface. The quality of the recording is ensured by the outstanding signal-to-noise ratio, as you can see from our video samples gallery.

Recording and stimulating capabilities for all your applications

CorePlate™1W 38/60

The CorePlate™1W 38/60 microelectrode array features 4,096 recording electrodes arranged in a 3.8 mm x 3.8 mm area, a perfect compromise for both cultures and brain tissues. Compared to previous chipset families, CorePlate™1W 38/60 achieves an improved signal-to-noise ratio by offering a recording mode where a subset electrode area can be accessed for ultra-low noise performance.

Moreover, every single recording electrode can also be used to release an electrical signal to your sample. The CorePlate™1W 38/60 provides a 3.8 mm x 3.8 mm grid of 4,096 electrodes for spatially accurate electrical stimulation at a cellular resolution.

Each microelectrode is 21 µm x 21 µm, with a 60 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

The CorePlate™1W 38/60 is based on the Khíron (Gen 3) chipset family and is compatible with BioCAM DupleX only.

Pre-coated Accura series

Thanks to the AziGrip4™ CELL+ surface functionalization technology developed incollaboration with SuSoS AG, Accura microelectrode arrays can be provided in a pre-coated, sterile and ready-to-use version for cell cultures. By removing the need for manual functional coating and sterilization, both preparation time and variability in cell cultures between MEAs are reduced. Furthermore, it provides a homogeneous and reliable adhesion of cells to substrate, thus increasing the success rate of your experiments.

At a glance

Recording and stimulating capabilities
for all your applications

HD-MEA Accura

Accura micreoelectrode array features 4096 recording electrodes arranged in a 3.8 mm x 3.8 mm area, a perfect compromise for both cultures and brain tissues. Compared to the previous chipset families, Accura achieves an improved signal to noise ratio by offering a recording mode where a subset electrode area can be accessed for ultra-low noise performances.

Moreover, every single recording electrode can also be used to release an electrical signal to your sample. In this way HD-MEA Accura provides a 3.8 mm x 3.8 mm grid of 4096 electrodes for spatially accurate electrical stimulation at a cellular resolution.

Each microelectrode is 21 µm x 21 µm, with a 60 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Accura is from Khíron (Gen 3) chipset family and can be used with BioCAM DupleX only.

Pre-coated Accura series

Thanks to the AziGrip4™ CELL+ surface functionalization technology developed in collaboration with SuSoS AG, Accura microelectrode arrays can be provided in a pre-coated, sterile and ready-to-use version for cell cultures. By removing the need for manual functional coating and sterilization, both preparation time and variability in cell cultures between MEAs are reduced. Furthermore it provides a homogeneous and reliable adhesion of your cells to the substrate, thus increasing the success rate of your experiments.

At a glance

Recording and stimulating capabilities
for all your applications

HD-MEA Accura

Pre-coated Accura series

Thanks to the AziGrip4™ CELL+ surface functionalization technology developed in collaboration with SuSoS AG, Accura microelectrode arrays can be provided in a pre-coated, sterile and ready-to-use version for cell cultures. By removing the need for manual functional coating and sterilization, both preparation time and variability in cell cultures between MEAs are reduced. Furthermore it provides a homogeneous and reliable adhesion of your cells to the substrate, thus increasing the success rate of your experiments.

At a glance

More space to accommodate large tissues

CorePlate™1W 27/42L

CorePlate™1W 27/42L has the same microelectrode recording array as the CorePlate™ 1W 27/42 (4,096 electrodes in a 2.67 mm x 2.67 mm area), but offers a larger surrounding flat area (~6 mm x 6 mm), which is ideal for positioning large tissues while guaranteeing optimal coupling with the microelectrode array.

Each microelectrode is 21 µm x 21 µm, with a pitch of 42 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.
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The CorePlate™ 1W 27/42 is based on the Artemis (Gen 2) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

More space to accommodate large tissues

HD-MEA Arena

Arena has the same microelectrode recording array as the Prime model (4,096 electrodes in a 2.67 mm x 2.67 mm area), but offers a larger surrounding flat area (~6 mm x 6 mm), which is ideal for positioning large tissues while guaranteeing optimal coupling with the microelectrode array.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.
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HD-MEA Arena is from Artemis (Gen2) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

More space to accommodate large tissues

HD-MEA Arena

At a glance

Largest sensing area and stimulation capabilities

CorePlate™ 1W 51/81

The CorePlate™ 1W 51/81 features a large sensing area (5.12 mm x 5.12 mm) with an increased electrode pitch of 81 µm. This makes it possible to record electrophysiological activity from large portions of neuronal tissue while maintaining a high spatial resolution.

The CorePlate™ 1W 51/81 model also features a secondary array for stimulation with 16 microelectrodes, arranged in a 4 x 4 uniform grid, that are interspersed between the recording electrodes.

The electrode size for both recording and stimulating electrodes is 21 µm x 21 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.
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CorePlate™ 1W 51/81 is based on the Artemis (Gen 2) chipset family. It can be used to its full extent with BioCAM X. Whereas when it is plugged into the BioCAM DupleX, its stimulation array is not supported and only recording is possible.

At a glance

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

The Stimulo HD-MEA features a large sensing area (5.12 mm x 5.12 mm) with an increased electrode pitch of 81 µm pitch. This makes it possible to record electrophysiological activity from large portions of neuronal tissue while maintaining a high spatial resolution.

Moreover, the Stimulo model features a secondary array for stimulation with 16 microelectrodes, arranged in a 4 x 4 uniform grid, that are interspersed between the recording electrodes.

The electrode size for both recording and stimulating electrodes is 21 µm x 21 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.
‍
HD-MEA Stimulo is based on the Artemis (Gen 2) chipset family. It can be used to its full extent with BioCAM X. Whereas when it is plugged into the BioCAM DupleX, its stimulation array is not supported and only recording is possible.

At a glance

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

At a glance

Ideal for cell cultures

CorePlate™ 1W 27/42

CorePlate™ 1W 27/42 is a high-density microelectrode array (HD-MEA) integrating 4,096 recording electrodes on a small and compact area of 2.67 mm x 2.67 mm, centered on a flat area of ~3 mm x 3 mm. This arrangement is ideal in reducing the number of seeded cells.
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Each microelectrode is 21 µm x 21 µm, with a pitch of 42 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.
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The CorePlate™ 1W 27/42 is based on the Apollo (Gen 1) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

Ideal for cell cultures

HD-MEA Prime

Prime is a high-density microelectrode array integrating 4,096 recording electrodes on a small and compact area of 2.67 mm x 2.67 mm, centered on a flat area of ~3 mm x 3 mm. This arrangement is ideal in reducing the number of seeded cells.
‍
Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.
‍
HD-MEA Prime is from Apollo (Gen 1) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

Ideal for cell cultures

HD-MEA Prime

At a glance

Tech specs

CorePlate™ 1W 38/60

Main Electrode Array

Mode of operation

Recording and stimulation

# of electrodes

4,096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

3.84 mm x 3.84 mm

Electrode size

21 µm x 21 µm

Electrode pitch

60 µm

Working Area

Flat area size

~6 mm x 6 mm

CorePlate™ 1W 27/42L

Main Electrode Array

Mode of operation

Recording

# of electrodes

4,096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

2.67 mm x 2.67 mm

Electrode size

21 µm x 21 µm

Electrode pitch

42 µm

Working Area

Flat area size

~6 mm x 6 mm

CorePlate™ 1W 51/81

Main Electrode Array

Mode of operation

Recording

# of electrodes

4,096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

5.12 mm x 5.12 mm

Electrode size

21 µm x 21 µm

Electrode pitch

81 µm

Second Electrode Array

Mode of operation

Stimulation

# of electrodes

16 arranged in a 4 x 4 grid and uniformly interspersed between main array

Electrodes' area size (active area)

3.96 mm x 3.96 mm

Electrode size

21 µm x 21 µm

Electrode pitch

1.3 mm

Working Area

flat area size

~6 mm x 6 mm

CorePlate™ 1W 27/42

Main Electrode Array

Mode of operation

Recording

# of electrodes

4,096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

2.67 mm x 2.67 mm

Electrode size

21 µm x 21 µm

Electrode pitch

42 µm

Working Area

Flat area size

~3 mm x 3 mm

Single-Well HD-MEAs

High-density microelectrode arrays with large sensing areas

Overview

The perfect tool for your brain research

Recording and stimulating capabilities for all your applications

CorePlate™1W 38/60

Pre-coated Accura series

Recording and stimulating capabilities for all your applications

HD-MEA Accura

Pre-coated Accura series

Recording and stimulating capabilities for all your applications

HD-MEA Accura

Pre-coated Accura series

More space to accommodate large tissues

CorePlate™1W 27/42L

More space to accommodate large tissues

HD-MEA Arena

More space to accommodate large tissues

HD-MEA Arena

Largest sensing area and stimulation capabilities

CorePlate™ 1W 51/81

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

Ideal for cell cultures

CorePlate™ 1W 27/42

Ideal for cell cultures

HD-MEA Prime

Ideal for cell cultures

HD-MEA Prime

Tech specs

CorePlate™ 1W 38/60

CorePlate™ 1W 27/42L

CorePlate™ 1W 51/81

CorePlate™ 1W 27/42

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Recording and stimulating capabilities
for all your applications

Recording and stimulating capabilities
for all your applications