Brain Slice Electrophysiology

Boost neuronal circuitry studies through functional brain tissue imaging

Models

Acute brain slices
Organotypic brain slices

Advantages

Our single-well and multiwell CorePlate™ can record both spiking activity and field potential propagations (fEPSP, Population Spikes) over different regions in brain tissue preparations at unprecedented spatial and temporal resolutions.

Advantages of 3Brain technology with brain slice imaging are:

Large brain region monitoring of spontaneous activity patterns and precise mapping of activity propagation over multiple circuits
Precise electrical stimulation capability
Automated LTP/LTD protocols for plasticity studies.
See Evos
Finely resolve signals from dendritic compartments or somatic layers within sub-areas of the circuitry

Click here to know how the technology works

Tools & Features

Brain Slices - Integrated spike/LFP detection and sorting algorithms

Integrated spike/LFP detection and sorting algorithms
Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity

Real-time and off-line filtering capabilities from fast spiking activities - 3Brain

Real-time and off-line filtering capabilities
A complete set of different filters (high pass, low pass and band pass) can be selected to separate slow field waves from fast spiking activity

Superimpose and Focus on BrainWave - 3Brain

Superimpose and Focus
Tissue sample image can be superimposed on the activity map to record selected region of interests or to focus on a specific area of activity for advanced analysis

Built-in stimulating capabilities with the BrainWave software - 3Brain

Built-in stimulating capabilities
Electrically evoked field potential responses can be investigated by using the internal stimulator of the BioCAM systems

Feel free to get in contact with our neuroscientists team for details

Customer experience

A collection of reviews from our customers

Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.

Prof. Egidio D’Angelo

University of Pavia Link to Author’s Publication

3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.

Dr. Ryley Parrish

Xenon Pharmaceuticals Inc.

The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.

Dr. Matthias H. Hennig

Computational Neuroscience and Neuroinformatics Link to Author’s Publication

The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.

Prof. Evelyne Sernagor

Retinal Neuroscience Link to Author’s Publication

It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Dr. Fred Jordan, Co-CEO

FinalSpark

The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.

Prof. Alysson Muotri

Institute for Genomic Medicine

We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.

Dr. Hayder Amin

Biohybrid Neuroelectronics Lab Link to Author’s Publication

I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Prof. Kim SangSeong

Hanyang University College of Pharmacy

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Michele Dipalo, PhD

Plasmon Nanotechnologies group at the Italian Institute of Technology (IIT)Link to Author’s Publication