A new frontier in functional imaging

The 6-well CorePlate™-powered microelectrode array platform designed for both cell culture and tissue preparations

Overview

Your companion in functional cell screening

Thanks to the CorePlate™ technology, HyperCAM Alpha delivers high resolution functional screening in a multiwell format.

The controlled environment allows label-free in vitro assays over long time periods. The large sensing area of the per-well integrated microchip provides room for measuring either cell cultures, brain slices or brain organoids.

Alpha is equipped with the latest generation of FPGA accelerators to manage real-time high-resolution data from up to 13824 (2304 per well) simultaneously recorded electrodes.

Complex operations are handled by the sophisticated system so you can focus on measuring the functional properties of neurons.

High Density Multiwell MEA for High Definition Results

HyperCAM Alpha is a multiwell HD-MEA platform designed to parallel experiments with neuronal cultures, organoids and brain slices. 4096 fully bidirectional electrodes (recording/stimulation) per well allow the real time characterization of neuronal diseases, mutations and effect of drugs at high statistical precision

High density multiwell sensors for high definition results

HyperCAM Alpha is a CorePlate™ powered 6 well platform that handles parallel experiments with neuronal cultures, organoids or brain slices. 4096 fully bidirectional electrodes (recording/stimulating) per well allow real time characterization of neuronal diseases, mutations and cell effectors with a high statistical precision.

Control over your experiments

The CorePlate™ multiwell is kept under control by accurately monitoring the temperature, CO₂ saturation and humidity of the environment your cells are exposed to. Additionally, the tag functionality of the CorePlate™ technology allows you to easily track your experiments.

The new golden standard for data collection & management

HyperCAM Alpha is coupled with the new BrainWave software to visualize and analyze complex network data from your preparation just in a click, providing the new gold standard for neuronal big data management.

The new golden standard for data collection & management

HyperCAM Alpha is coupled with the new BrainWave v.5 software to easily visualize and analyze network data from a multiwell configuration. Advanced data processing coupled to a smart user interface brings you one click away from charting any functional change in the network activity.

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HyperCAM Alpha multi-well system: A new frontier in functional imaging

The 6-well CorePlate™ -powered platform designed for both cell culture and tissue preparations

Overview

Your companion in functional cell screening

Thanks to the CorePlate™ technology, HyperCAM Alpha delivers high resolution functional screening platform in a multi-well plate format.
‍
The controlled environment allows label-free kinetic in vitro assays. The large sensing area of the per-well integrated microchip provides room for measuring either cell cultures, brain slices or brain organoids.
‍
Alpha is equipped with the latest generation of FPGA accelerators to manage real-time high-resolution data from up to 13,824 (2,304 per well) simultaneously recorded electrodes.
‍
Complex operations are handled by the sophisticated system so you can focus on measuring the functional properties of neurons.

Multiwell form factor with no compromise on data quality

Alpha accelerates your time-to-results without giving up any details

Parallelization does not have to be achieved at the cost of sacrificing data quality. Thanks to the CorePlate™ 6W 38/60, Alpha provides thousands of electrodes per-well that can be arranged in different recording configurations to satisfy any experimental needs. The high statistical quality of the data generated by each well reduces the overall needs of replicates. While also giving access to single-cell details with a spatio-temporal resolution comparable to that provided by our single well CorePlate™.

HyperCAM Alpha with CorePlate™ powered multiwell plate

Multiwell form factor with no compromise on data quality

Alpha accelerates your time-to-results without giving up any details

Parallelization does not have to be achieved at the cost of sacrificing data quality. Thanks to the 6-well CorePlate™ technology, Alpha provides thousands of electrodes per-well that can be arranged in different recording configurations to satisfy any experimental needs. The high statistical quality of the data generated by each well reduces the overall needs of replicates. While also giving access to single-cell details with a spatio- temporal resolution comparable to that provided by our single well HD-MEAs.

HyperCAM Alpha view with CorePlate™ powered multiwell plate

Flexibility for your experimental needs

One system, multiple purposes

Regardless of whether you want to record human iPSC-derived neurons, dissociated murine cultures, acute brain and cardiac tissues, complex 3D neuronal assemblies, spheroids or brain organoids, HyperCAM Alpha is always your best choice.

Alpha leaves the freedom to operate with the chamber closed to provide incubator-like conditions for long term recordings as well as in an open configuration for acute measurement requiring the integration of fluidic systems. In both cases, optical access is guaranteed to always keep your preparations under control.

Smart and simple

A concentration of high-tech solutions to simplify experimental procedures

HyperCAM Alpha is designed to reduce experimental hassles and allows you to fully concentrate on the most important thing: your assay.
‍
The CorePlate™ multiwell’s environment is regulated by accurately controlling the temperature, CO₂ saturation and humidity through the software or even the integrated touchscreen.
‍
The incubation chamber is water-proof to protect instrument electronics from accidental spill-out or experimental misuse.
‍
The combination with the latest BrainWave software allows to easily visualize and analyze data from CorePlate™ microchips.

Tech specs

Main Controller

Computational core

Intel®’s Arria® 10 FPGA 13Gbps, 2GB DDR4,
and ARM® dual-core Cortex™-A9 1.5 GHz

Data resolution

14 bit

Compatible with

CorePlate™ 6W 38/60

Number of simultaneous recording channels

13,824 (2304 per well) @10kHz
or 6,144 (1024 per well) @20kHz

Environmental chamber

With controlled temperature and CO₂
concentration (via integrated air mixer)
and with monitored humidity

Touch screen

100k dots to read and set status of
environmental chamber values and
perform basic operations
(e.g., read/set temperature and
reset parameters, lock/unlock the
CorePlate™ device, etc.)

Data interface

USB 3.1 Type-C data interface

Control software compatibility

BrainWave 5 or higher

Stimulation Module

Integrated current stimulator

Yes

Number of independent channels

Stimulation sites

24,576 (4,096 per well)

Maximum amplitude

+/- 1 mA

Amplitude resolution

10 µA

Time resolution

10 µs

Physical specs

Body material

Plastic

Chamber lid

Movable lid with transparent window that
can be operated either by the software or
manually

Locking mechanism

Motorized CorePlate™ locking system

Protection from liquid spill over

Chamber protected against dripping water

Dimensions
(W x D x H)

417 x 248 x 154 mm

Weight

8.5 Kg / 18.7 pounds

A new frontier in functional imaging

Overview

Your companion in functional cell screening

High Density Multiwell MEA for High Definition Results

High density multiwell sensors for high definition results

Control over your experiments

Control over your experiments

The new golden standard for data collection & management

The new golden standard for data collection & management

Sign-Up for HyperCAM Alpha Updates

Message

HyperCAM Alpha multi-well system: A new frontier in functional imaging

Overview

Your companion in functional cell screening

Multiwell form factor with no compromise on data quality

Alpha accelerates your time-to-results without giving up any details

Multiwell form factor with no compromise on data quality

Alpha accelerates your time-to-results without giving up any details

Flexibility for your experimental needs

One system, multiple purposes

Smart and simple

A concentration of high-tech solutions to simplify experimental procedures

CorePlate™ Multiwells

BrainWave 5

CorePlate™ Multiwells

BrainWave 5

Resources

Tech specs

Main Controller

Stimulation Module

Physical specs

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