Neuronal cell culture and stem cell cultures

Explore new pathways in brain research and drug discovery

Models

Human iPSC-derived neuronal culture
Neural progenitor derived cultures
Primary neuronal cell culture

Advantages

Our single-well and multiwell CorePlate™, based on high density microelectrode array technology, allow studying of the physiological and pathological functional activity of neuronal cultures. A versatile tool to investigate in detail the mechanisms of neuronal signal processing and to improve the quality and reliability of drug screenings or toxicological assays.

Advantages of using 3Brain technology on neuronal cultures:

Label-free functional monitoring of large networks with single-cell spiking activity resolution
Tracking of signal propagation among cells for functional connectivity studies
Kinetic functional assay to follow culture development over weeks and months
Improved statistical significance of the calculated network activity parameters

Click here to know how the technology works

Tools & Features

Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity - 3Brain

Integrated spike detection and sorting algorithms
Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity

Automated statistical analysis of network parameters - 3Brain

Automated statistical analysis of network parameters
The all-in-one BrainWave software will assist you in quickly obtaining results from your experimental session in a simple and intuitive way

Built-in stimulating capabilities - Investigate electrically evoked neural network responses by using the internal stimulator of the BioCAM systems and HyperCAM systems

Built-in stimulating capabilities
Investigate electrically evoked neural network responses by using the internal stimulator of the BioCAM systems and HyperCAM systems

Feel free to get in contact with our neuroscientists team for details

Customer experience

A collection of reviews from our customers

The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.

Dr. Matthias H. Hennig

Computational Neuroscience and Neuroinformatics See Link to Author’s Publication

We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.

Dr. Hayder Amin

Biohybrid Neuroelectronics Lab See Link to Author’s Publication

I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Prof. Kim SangSeong

Hanyang University College of Pharmacy

Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.

Prof. Egidio D’Angelo

University of Pavia See Link to Author’s Publication

The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.

Prof. Evelyne Sernagor

Retinal Neuroscience See Link to Author’s Publication

It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Dr. Fred Jordan, Co-CEO

FinalSpark

The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.

Prof. Alysson Muotri

Institute for Genomic Medicine

3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.

Dr. Ryley Parrish

Xenon Pharmaceuticals Inc.

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Michele Dipalo, PhD

Plasmon Nanotechnologies group at the Italian Institute of Technology (IIT)Link to institution

Resources

Location to specific products and samples within 3Brain's resources

Selected Publications

View all

Neuronal Cultures

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

(paper)

Tucci V., Kleefstra T., Hardy A., Heise I., Maggi S., Willemsen M. H., Hilton H., Esapa C., Simon M., Buenavista M-T., McGuffin L. J., Vizor L., Dodero L., Tsaftaris S., Romero R., Nillesen W. N., Vissers L.E.L.M., Kempers M. J., Vulto-van Silfhout A. T., Iqbal Z., Orlando M., Maccione A., Lassi G., Farisello P., Contestabile A., Tinarelli F., Nieus T., Raimondi A., Greco B., Cantatore D., Gasparini L., Berdondini L., Bifone A., Gozzi A., Wells S., Nolan P. M.

The Journal of Clinical Investigation DOI: 10.1172/JCI70372

Neuronal Cultures

Electrical and chemical modulation of homogeneous and heterogeneous human-iPSCs-derived neuronal networks on high density arrays

(paper)

Parodi G., Zanini G., Chiappalone M., Martinoia S.

Front. Mol. Neurosci. (2024). DOI: 10.3389/fnmol.2024.1304507

Neuronal Cultures

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons

(paper)

Hergenreder E, Minotti AP, Zorina Y, Oberst P, Zhao Z, Munguba H, Calder EL, Baggiolini A, Walsh RM, Liston C, Levitz J, Garippa R, Chen S, Ciceri G, Studer L.

Nature Biotechnology (2024) DOI: 10.1038/s41587-023-02031-z

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Probing intelligent networks

Neuronal cell culture and stem cell cultures

Models

Advantages

Tools & Features

Customer experience

Resources

Selected Publications

Neuronal Cultures

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

Neuronal Cultures

Electrical and chemical modulation of homogeneous and heterogeneous human-iPSCs-derived neuronal networks on high density arrays

Electrical and chemical modulation of homogeneous and heterogeneous human-iPSCs-derived neuronal networks on high density arrays

Neuronal Cultures

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons

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