Ex-vivo acute retinal explant

Shed light on retinal activity in vitro. Record responses to light stimuli and generate retinal ganglion cells (RGCs) mosaics.

Models

Whole mount retina explants
Primate and non-primate retina tissues

Advantages

Explanted retinas from different animal models (e.g. murine, salamander, primates, etc.) can be studied up-close on our single-well or multiwell CorePlate™. With the largest active microelectrode area on the market (up to 25mm²), they are optimized for recording single cell activity over large tissue samples.

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Advantages of 3Brain technology with explanted retinas are:

Entire retinal ganglion cell network mapping at single-cell resolution.
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Record light-induced retinal network activity by combining our BioCAM platform with light-stimulation devices.
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Combine with optogenetic stimulation tools for spatiotemporally precise excitation/inhibition of cells
Single cell visualization of signal propagation

Click here to know how the technology works

Tools & Features

Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity - 3Brain

Integrated spike/LFP detection and sorting algorithms
Run sophisticated analyses like spike-sorting to evaluate your results for statistical significance with BrainWave, our most elaborated retinal electrophysiology data analysis software.
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the HDF5 file format of BrainWave is fully compatibile with third-party softwares - 3Brain

Full compatibility with third-party softwares
HDF5 file format raw data readable with Python, Igor Pro, Matlab…Run your custom home made analysis routines.

3Brain's BrainWave software also synchronizes a light stimulator with our BioCAM systems - 3Brain

Synchronize light stimulator with BioCAM systems
Analog inputs or triggers (LV-TTL) lines can be used to synchronize and record light stimulation patterns with the BioCAM’s dataset.

Feel free to get in contact with our neuroscientists team for details

Customer experience

A collection of reviews from our customers

The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.

Prof. Evelyne Sernagor

Retinal Neuroscience See Link to Author’s Publication

The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.

Dr. Matthias H. Hennig

Computational Neuroscience and Neuroinformatics See Link to Author’s Publication

Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.

Prof. Egidio D’Angelo

University of Pavia See Link to Author’s Publication

It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Dr. Fred Jordan, Co-CEO

FinalSpark

The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.

Prof. Alysson Muotri

Institute for Genomic Medicine

We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.

Dr. Hayder Amin

Biohybrid Neuroelectronics Lab See Link to Author’s Publication

I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Prof. Kim SangSeong

Hanyang University College of Pharmacy

3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.

Dr. Ryley Parrish

Xenon Pharmaceuticals Inc.

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Michele Dipalo, PhD

Plasmon Nanotechnologies group at the Italian Institute of Technology (IIT)See Link to Author’s Publication

Resources

Location to specific products and samples within 3Brain's resources

Selected Publications

View all

Acute Retina

Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array

(paper)

Gergely Szarka, Alma Ganczer, Márton Balogh, Ádám Jonatán Tengölics, Anett Futácsi, Garrett Kenyon, Feng Pan, Tamás Kovács-Öller, Béla Völgyi

iScience (2024). DOI: 10.1016/j.isci.2024.110099

Acute Retina

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration

(paper)

Cupini S, Di Marco S, Boselli L, Cavalli A, Tarricone G, Mastronardi V, Castagnola V, Colombo E, Pompa PP, Benfenati F.

ACS Nano (2023) DOI: 10.1021/acsnano.3c07517

Acute Retina

Birds multiplex spectral and temporal visual information via retinal On- and Off-channels

(paper)

Seifert M., A. Roberts P., Kafetzis G., Osorio D. and Baden T.

Nature Communications (2023). DOI: 10.1038/s41467-023-41032-z

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Probing intelligent networks

Ex-vivo acute retinal explant

Models

Advantages

Tools & Features

Customer experience

Resources

Selected Publications

Acute Retina

Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array

Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array

Acute Retina

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration

Acute Retina

Birds multiplex spectral and temporal visual information via retinal On- and Off-channels

Birds multiplex spectral and temporal visual information via retinal On- and Off-channels

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