Retina & further applications

Discover how high resolution can help in studying the processing pathways of retina and explore other applications

Overview

Retina

Explanted retinas from different animal models (e.g. murine, salamander, primates etc...) can be coupled with the microelectrode active area of our high density Multielectrode Array recording either spontaneous or light-induced activity generated by the retinal ganglion cell layer. See more

Our high resolution technology allows to:

  • Map the activity of the entire retinal ganglion cell layer at single cell resolution. See more videos

  • Record light-induced network activity by combining the BioCAM with light-stimulation devices. See all videos
The spatial extent (from 7.1 mm2 up to 26.2 mm2) of the HD-MEA allows to record simultaneously from large retinal areas. Adapted from G. Hilgen et al., Sci. Rep. 2017. See more

Optogenetics

High density Microelectrode Array can also be combined with optogenetic stimulation tools for spatiotemporally precise excitation/inhibition of cells, as in the aside image, where optogenetics was successfully used in a study on retinitis pigmentosa. See more

High resolution can be exploited to assess light sensitivity by using sophisticated stimuli inspired by those used in clinical visual assessment. Adapted from J.M. Barrett et al., Sci. Rep. 2016. See more

To discuss further possibilities, please contact us.