3Brain - Publications

Acute Brain Slices

High-Quality Seizure-Like Activity from Acute Brain Slices Using a Complementary Metal-Oxide-Semiconductor High-Density Microelectrode Array System

(paper)

Blotter, M. L., Stubbs, I. W., Norby, J. H., Holmes, M., Kearsley, B., Given, A., Hine, K., Shepherd, M. R., Parrish, R. R.

J. Vis. Exp. (2024). DOI:10.3791/67065

Acute Brain Slices

Milestone White Paper 1

(white paper)

Cradle

Cradle. (2024).

Organoids

Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei

(paper)

Wei Pang, Jinkui Zhu, Kexin Yang, Xiaona Zhu, Wei Zhou, Linlin Jiang, Xuran Zhuang, Yantong Liu, Jianfeng Wei, Xiaoxiang Lu, Yao Yin, Ziling Chen, Yangfei Xiang

Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.08.004

Organoids

Brain Chimeroids reveal individual susceptibility to neurotoxic triggers

(paper)

Noelia Antón-Bolaños, Irene Faravelli, Tyler Faits, Sophia Andreadis, Rahel Kastli, Sebastiano Trattaro, Xian Adiconis, Anqi Wei, Abhishek Sampath Kumar, Daniela J. Di Bella, Matthew Tegtmeyer, Ralda Nehme, Joshua Z. Levin, Aviv Regev & Paola Arlotta

Nature (2024). DOI: 10.1038/s41586-024-07578-8

Organoids

Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress

(paper)

Hannah C. Leeson, Julio Aguado, Cecilia Gómez-Inclán, Harman Kaur Chaggar, Atefah Taherian Fard, Zoe Hunter, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang

Neurobiology of Disease Vol. 199 (2024). DOI: https://doi.org/10.1016/j.nbd.2024.106562

Acute Retina

Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array

(paper)

Gergely Szarka, Alma Ganczer, Márton Balogh, Ádám Jonatán Tengölics, Anett Futácsi, Garrett Kenyon, Feng Pan, Tamás Kovács-Öller, Béla Völgyi

iScience (2024). DOI: 10.1016/j.isci.2024.110099

Organoids

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

(paper)

Mohammed R. Shaker , Andrii Slonchak , Bahaa Al-Mhanawi, Sean D. Morrison , Julian D. J. Sng , Justin Cooper-White , Alexander A. Khromykh, Ernst J. Wolvetang

SCIENCE ADVANCES. 5 Jun 2024. Vol 10, Issue 23. DOI: 10.1126/sciadv.adj4735

Acute Brain Slices

Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity

(paper)

Galanis C., Neuhaus L., Hananeia N., Turi Z., Jedlicka P., Vlachos A.

Front. Cell. Neurosci. (2024). DOI: 10.3389/fncel.2024.1374555

Neuronal Cultures

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

(paper)

Tucci V., Kleefstra T., Hardy A., Heise I., Maggi S., Willemsen M. H., Hilton H., Esapa C., Simon M., Buenavista M-T., McGuffin L. J., Vizor L., Dodero L., Tsaftaris S., Romero R., Nillesen W. N., Vissers L.E.L.M., Kempers M. J., Vulto-van Silfhout A. T., Iqbal Z., Orlando M., Maccione A., Lassi G., Farisello P., Contestabile A., Tinarelli F., Nieus T., Raimondi A., Greco B., Cantatore D., Gasparini L., Berdondini L., Bifone A., Gozzi A., Wells S., Nolan P. M.

The Journal of Clinical Investigation DOI: 10.1172/JCI70372

Acute Brain Slices

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Brett Addison Emery, Shahrukh Khanzada, Xin Hu, Diana Klütsch, Hayder Amin

J. Vis. Exp. (2024). DOI: 10.3791/66473

Acute Brain Slices

Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo

(paper)

Goodchild S.J., Shuart N.G., Williams A.D., Ye W., Parrish R.R., Soriano M., Thouta S., Mezeyova J., Waldbrook M., Dean R., Focken T., Ghovanloo M.R., Ruben P.C., Scott F., Cohen C.J., Empfield J., Johnson JP.

ACS Chem. Neurosci. (2024) DOI: 10.1021/acschemneuro.3c00757

Neuronal Cultures

Electrical and chemical modulation of homogeneous and heterogeneous human-iPSCs-derived neuronal networks on high density arrays

(paper)

Parodi G., Zanini G., Chiappalone M., Martinoia S.

Front. Mol. Neurosci. (2024). DOI: 10.3389/fnmol.2024.1304507

Acute Brain Slices

Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development

(paper)

Tagliatti, E., Desiato, G., Mancinelli, S., Bizzotto, M., Gagliani, M. C., Faggiani, E., Hernández-Soto, R., Cugurra, A., Poliseno, P., Miotto, M., Argüello, R. J., Filipello, F., Cortese, K., Morini, R., Lodato, S., & Matteoli, M.

Immunity (2024). DOI: 10.1016/j.immuni.2023.12.002

Neuronal Cultures

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons

(paper)

Hergenreder E, Minotti AP, Zorina Y, Oberst P, Zhao Z, Munguba H, Calder EL, Baggiolini A, Walsh RM, Liston C, Levitz J, Garippa R, Chen S, Ciceri G, Studer L.

Nature Biotechnology (2024) DOI: 10.1038/s41587-023-02031-z

Cardiomyocyte

Multi-chamber cardioids unravel human heart development and cardiac defects

(paper)

Schmidt C., Deyett A., Ilmer T., Haendeler S., Caballero A. T., Novatchkova M., Netzer M. A., Ginistrelli L. C., Juncosa E. M., Bhattacharya T., Mujadzic A., Pimpale L., Jahnel S. M., Cirigliano M., Reumann D., Tavernini K., Papai N., Hering S., Hofbaur P., Mendjan S.

Cell (2023) DOI: 10.1016/j.cell.2023.10.030

Acute Brain Slices

Low glycemic index diet restrains epileptogenesis in a gender-specific fashion

(paper)

Michetti, C., Ferrante, D., Parisi, B., Ciano, L., Prestigio, C., Casagrande, S., Martinoia, S., Terranova, F., Millo, E., Valente, P. and Giovedi’, S.,

Cellular and Molecular Life Sciences (2023) DOI: 10.1007/s00018-023-04988-1

Acute Retina

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration

(paper)

Cupini S, Di Marco S, Boselli L, Cavalli A, Tarricone G, Mastronardi V, Castagnola V, Colombo E, Pompa PP, Benfenati F.

ACS Nano (2023) DOI: 10.1021/acsnano.3c07517

Acute Brain Slices

Recording Network-based Synaptic Transmission and LTP in the Hippocampal Network on a Large-scale Biosensor

(paper)

Emery, B. A., Khanzada, S., Hu, X., Rossi, L., Klütsch, D., Altuntac, E., & Amin, H

IEEE BioSensors Conference (BioSensors) (2023) DOI: 10.1109/BioSensors58001.2023.10280958

Acute Brain Slices

High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity

(paper)

Emery, B.A., Hu, X., Khanzada, S., Kempermann, G. and Amin, H.,

Biosensors and Bioelectronics (2023) DOI: 10.1016/j.bios.2023.115471

Acute Brain Slices

Alteration of neural network and hippocampal slice activation through exosomes derived from 5XFAD nasal lavage fluid

(paper)

Kim S., Jeon J., Ganbat D., Kim T., Shin K., Hong S. and Hong J.

Int. J. Mol. Sci. (2023) DOI: 10.3390/ijms241814064

Acute Retina

Birds multiplex spectral and temporal visual information via retinal On- and Off-channels

(paper)

Seifert M., A. Roberts P., Kafetzis G., Osorio D. and Baden T.

Nature Communications (2023). DOI: 10.1038/s41467-023-41032-z

Organoids

Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light

(paper)

Celiker, C., Weissova, K., Cerna, K.A., Oppelt, J., Dorgau, B., Gambin, F.M., Sebestikova, J., Lako, M., Sernagor, E., Liskova, P. and Barta, T.,

Iscience (2023) DOI: 10.1016/j.isci.2023.107237

Acute Brain Slices

Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings

Monteverdi A., Di Domenico D., D’Angelo E., Mapelli L.

Biomedicines (2023). DOI: 10.3390/biomedicines11051475

Cardiomyocyte

Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation

(paper)

Inácio JM, Nunes MM, Almeida M, Cristo F, Anjos R, Belo JA.

Cells. 2023; 12(4):520. DOI: 10.3390/cells12040520

Acute Brain Slices

Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

(paper)

Xie S-T., Fan W-C., Zhao X-S., Ma X-Y., Li Z-L., Zhao Y-R., Yang F., Shi Y., Rong H., Cui Z-S., Chen J-Y., Li H-Z., Yan C., Zhang O., Wang J-J., Zhang X-Y., Gu X-P., Ma Z-L. and Zhu J-N.

Pharmacological Research (2023). DOI: 10.1016/j.phrs.2023.106773

Organoids

Human-derived cortical neurospheroids coupled to passive, high-density and 3D MEAs: a valid platform for functional tests

(paper)

Muzzi L., Di Lisa D., Falappa M., Pepe S., Maccione A., Pastorino L., Martinoia S. and Frega M.

Bioengineering (2023) DOI: 10.3390/bioengineering10040449

Neuronal Cultures

Exploring the Pathological Effect of Aβ42 Oligomers on Neural Networks in Primary Cortical Neuron Culture

(paper)

Ganbat D., Kyong Jeon J. and Lee Y.

Int. J. Mol. Sci. (2023) DOI: 10.3390/ijms24076641

Neuronal Cultures

Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression

(paper)

Giansante G., Mazzoleni S., G. Zippo A., Ponzoni L. Ghilardi A., Maiellano G., Lewerissa E., van Hugte E., Nadif Kasri N., Francolini M., Sala M., Murru L., Bassani S. and Passafaro M.

Mol Psychiatry (2023). DOI: 10.1038/s41380-023-02022-1

Acute Brain Slices

Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression

(paper)

Giansante, G., Mazzoleni, S., Zippo, A.G., Ponzoni, L., Ghilardi, A., Maiellano, G., Lewerissa, E., van Hugte, E., Nadif Kasri, N., Francolini, M. and Sala, M.,

Molecular Psychiatry (2023) DOI: 10.1038/s41380-023-02022-1

Acute Brain Slices

A deep generative adversarial network capturing complex spiral waves in disinhibited circuits of the cerebral cortex

(paper)

Boucher-Routhier M. and Thivierge JP.

BMC Neuorscience (2023) DOI: 10.1186/s12868-023-00792-6

Acute Brain Slices

An in vitro model of drug-resistant seizures for selecting clinically effective antiseizure medications in Febrile Infection-Related Epilepsy Syndrome

(paper)

Cerovic, M., Di Nunzio, M., Craparotta, I., & Vezzani, A.

Front. Neurol. (2023). DOI: 10.3389/fneur.2023.1129138

Acute Brain Slices

Lipid-accumulated reactive astrocytes promote disease progression in epilepsy

Chen Z-P., Wang S., Zhao X., Fang W., Wang Z., Ye H., Wang M-J., Ke L., Huang T., Lv L., Jiang X., Zhang Q.,Li L., Xie S-T., Zhu Y-N., Hang C., Chen D., Liu X., Yan C.

Nature Neuroscience (2023). DOI: 10.1038/s41593-023-01288-6

Other Models

hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease

(paper)

Fan, Y., Hackland, J., Baggiolini, A., Hung, L. Y., Zhao, H., Zumbo, P., Oberst, P., Minotti, A. P., Hergenreder, E., Najjar, S., Huang, Z., Cruz, N. M., Zhong, A., Sidharta, M., Zhou, T., de Stanchina, E., Betel, D., White, R. M., Gershon, M., Margolis, K. G., … Studer, L.

Cell Stem Cell. (2023). DOI: 10.1016/j.stem.2023.02.003

Organoids

Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

(paper)

Chichagova V., Georgiou M., Carter M., Dorgau B., Hilgen G., Collin J., Queen R., Chung G., Ajeian J., Moya-Molina M., Kustermann S., Pognan F., Hewitt P., Schmitt M., Sernagor E., Armstrong L. and Lako M.

Journal of Cellular and Molecular Medicine (2023). DOI: 10.1111/jcmm.17670

Acute Brain Slices

Network synaptic plasticity of cerebellum in a model of paroxysmal dystonia

(paper)

Santana-Kragelund F., Franz D., Heerdegen M., Lüttig A., Perl Perl S., Richter A., Köhling R.

Brain Stimul. (2023). DOI: 10.1016/j.brs.2023.01.444

Acute Retina

Glial Bmal1 role in mammalian retina daily changes

(paper)

Riccitelli S., Boi F., Lonardoni D., Giantomasi L., Barca-Mayo O., De Pietri Tonelli D., Bisti S., Di Marco S. and Berdondini L.

Scientific Reports (2022). DOI: 10.1038/s41598-022-25783-1

Acute Brain Slices

Large-scale Multimodal Recordings on a High-density Neurochip: Olfactory Bulb and Hippocampal Networks

Emery B. A., Hu X., Muageri L., Khanzada S., Klutsch D., Altuntac E., Amin H

IEEE Engineering in Medicine & Biology Society (EMBC), (2022) DOI:10.1109/EMBC48229.2022.9871961

Neuronal Cultures

Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning

(paper)

Jia, X., Shao, W., Hu, N., Shi, J., Fan, X., Chen, C., Wang, Y., Chen, L., Qiao, H., & Li, X.

Front Neurosci. (2022). DOI: 10.3389/fnins.2022.854199

Acute Brain Slices

Xenon LFP Analysis Platform Is a Novel Graphical User Interface for Analysis of Local Field Potential From Large-Scale MEA Recordings

(paper)

Mahadevan A., Codadu N.K. and Parrish R.R.

Frontiers in Neuroscience (2022). DOI: 10.3389/fnins.2022.904931

Acute Brain Slices

Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia

(paper)

Veleanu M., Urrieta-Chávez B., Sigoillot S. M., and Selimi F.

PNAS (2022). DOI: 10.1073/pnas.2122544119

Acute Retina

Receptive field estimation in large visual neuron assemblies using a super-resolution approach

(paper)

Pamplona D., Hilgen G., Hennig M.H., Cessac B., Sernagor E., and Kornprobst P.

Journal of Neurophysiology (2022). DOI: 10.1152/jn.00076.2021

Neuronal Cultures

Revealing directed effective connectivity of cortical neuronal networks from measurements

(paper)

Sun C., Lin K.C., Yeung Y., Ching E.S.C., Huang Y., Lai P., and Chan C.K.

APS Physics (2022). DOI: 10.1103/PhysRevE.105.044406

Acute Brain Slices

Hypoxia induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain

(paper)

Lobo M.E.D.V., Weir N., Hardowar L., Al Ojaimi Y., Madden R., Gibson A., Bestall S.M., Hirashima M., Schaffer C.B., Donaldson L.F., Bates D.O. and Hulse R.P.

PAIN (2022). DOI: 10.1097/j.pain.0000000000002627

Acute Brain Slices

Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics

(paper)

Tognolina M., Monteverdi A., and D'Angelo E.

Frontiers in Cellular Neuroscience (2022). DOI: 10.3389/fncel.2022.805670

Acute Retina

A novel approach to the functional classification of retinal ganglion cells

(paper)

Hilgen G., Kartsaki E., Kartysh V., Cessac B. and Sernagor E.

Open Biol (2022). DOI: 0.1098/rsob.210367

Neuronal Cultures

Heterogeneous Responses to Changes in Inhibitory Synaptic Strength in Networks of Spiking Neurons

(paper)

Li, H. Y., Cheng, G. M., & Ching, E. S. C.

Front Cell Neurosci. (2022). DOI: 10.3389/fncel.2022.785207

Organoids

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: a Comprehensive Validation Using Drugs and Compounds Affecting the Retina

(paper)

Dorgau B., Georgiou M., Chaudhary A., Moya-Molina M., Collin J., Queen R., Hilgen G., Davey T., Hewitt P., Schmitt M., Kustermann S., Pognan F., Steel D. H., Sernagor E., Armstrong L., and Lako M.

Stem Cells Transl Med. (2022). DOI: 10.1093/stcltm/szab010

Acute Brain Slices

Implementation of biohybrid olfactory bulb on a high-density CMOS-chip to reveal large-scale spatiotemporal circuit information

(paper)

Hu X., Khanzada S., Klütsch D.,Calegari F., and Amin H.

Biosensors and Bioelectronics (2022). DOI: 10.1016/j.bios.2021.113834

Acute Brain Slices

Non-Linear Frequency Dependence of Neurovascular Coupling in the Cerebellar Cortex Implies Vasodilation–Vasoconstriction Competition

(paper)

Gagliano G., Monteverdi A., Casali S., Laforenza U., Gandini Wheeler-Kingshott C.A.M., D'Angelo E., and Mapelli L.

Cells (2022). DOI: 10.3390/cells11061047

Acute Brain Slices

3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis

(paper)

Shao C., Liu Y., Chen Z., Zhu H., Zhao J. and Qian Y.

Cell Chemical Biology (2021). DOI: 10.1016/j.chembiol.2021.12.006

Cardiomyocyte

All-Optical and Label-Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials

(paper)

Bruno G. , Melle G. , Barbaglia A. , Iachetta G., Melikov R., Perrone M., Dipalo M., and Angelis F.D.

Advanced Science (2021). DOI: 10.1002/advs.202100627

Acute Brain Slices

Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice

(paper)

Longatti A., Ponzoni L., Moretto E., Giansante G., Lattuada N., Colombo M.N., Francolini M., Sala M., Murru L. , and Passafaro M.

Mol Neurobiol. (2021). DOI: 10.1007/s12035-021-02502-x

Organoids

Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array

(conf. proc.)

Muzzi L. , Falappa M., Maccione A. , Di Lisa D. , Frega M. , and Martinoia S.

IEEE (2021) DOI: 10.1109/NER49283.2021.9441261

Neuronal Cultures

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

(paper)

Cutarelli A., Martínez-Rojas V.A., Tata A., Battistella I., Rossi D., Arosio D., Musio C., and Conti L.

Cells (2021). DOI: 10.3390/cells10051127

Acute Brain Slices

Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures

(paper)

Komulainen, E., Badman, J., Rey, S., Rulten, S., Ju, L., Fennell, K., Kalasova, I., Ilievova, K., McKinnon, P. J., Hanzlikova, H., Staras, K., & Caldecott, K. W.

EMBO Rep (2021). DOI: 10.15252/embr.202051851

Cardiomyocyte

Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays

(paper)

Iachetta G., Colistra N., Melle G., Deleye L., Tantussi F., Angelis F.D., and Dipalo M.

Toxicology and Applied Pharmacology (2021). DOI: 10.1016/j.taap.2021.115480

Acute Brain Slices

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

(paper)

Gonzalez-Calvo I., Iyer K., Carquin M., Khayachi A., Giuliani F. A., Sigoillot S. M., Vincent J., Seveno M., Veleanu M., Tahraoui S., Albert M., Vigy O., Bosso-Lefevre C., Nadjar Y., Dumoulin A., Triller A., Bessereau J-L., Rondi-Reig L., Isope P., and Selimi F.

eLife (2021) DOI: 10.7554/eLife.65712

Acute Retina

Transplanted pluripotent stem cell‐derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

(paper)

Zerti D., Hilgen G., Dorgau B., Collin J., Ader M., Armstrong L., Sernagor E., and Lako M.

Stem Cells Journal (2021). DOI: 10.1002/stem.3365

Acute Brain Slices

Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions

(paper)

Ixmatlahua D. J., Vizcarra B., Gómez-Lira G., Romero-Maldonado I., Ortiz F., Rojas-Piloni G. and Gutiérrez R.

The Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.2590-19.2020

Organoids

Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids

(paper)

Georgiou M., Chichagova V., Hilgen G., Dorgau B., Sernagor E., Armstrong L. and Lako M.

Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860

Acute Brain Slices

A Claustrum in Reptiles and its role in Slow-Wave Sleep

(paper)

Norimoto H., Fenk L. A., Li H., Tosches M. A., Gallego-Flores T., Hain D., Reiter S., Kobayashi R., Macias A., Arends A., Klinkmann M. and Laurent G.

Nature (2020). DOI: https://doi.org/10.1038/s41586-020-1993-6

Acute Retina

Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina

(paper)

Puller C., Duda S., Lotfi E., Arzhangnia Y., Block C. T., Ahlers M. T. and Greschner M.

Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.1374-19.2019

Signal Processing

Neural field models for latent state inference: Application to large-scale neuronal recordings

(paper)

Rule M. E., Schnoerr D., Hennig M. H. and Sanguinetti G.

PLOS Computational Biology (2019). DOI: https://doi.org/10.1371/journal.pcbi.1007442

Acute Retina

Investigating the Effects of Mechanical Stimulation on Retinal Ganglion Cell Spontaneous Spiking Activity

(paper)

Marrese M., Lonardoni D., Boi F., Hoorn H.V., Maccione A., Zordan S., Lannuzzi D. and Berdondini L.

Front. Cell. Neurosci. (2019). DOI: https://doi.org/10.3389/fnins.2019.01023

Neuronal Cultures

Transfer Entropy Based Connectivity Estimation of Spontaneously Firing Hippocampal Cultures on Multi Electrode Arrays

(conf. proc.)

Lama N., Hargreaves A.J., Stevens B., Mcginnity T.M.

International Joint Conference on Neural Networks (2019). DOI: 10.1109/IJCNN.2019.8851864

Organoids

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids

(paper)

Dorgau B., Felemban M., Hilgen G., Kiening M., Zerti D., Claire Hunt N., Doherty M., Whitfield P., Hallam D., White K., Ding Y., Krasnogar N., Al-Aama J., Z. Asfour H., Sernagor E., Lako M.

Science Direct (2019) DOI: 10.1016/j.biomaterials.2019.01.028

Acute Brain Slices

Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons

(paper)

Valente, P., Romei, A., Fadda, M., Sterlini, B., Lonardoni, D., Forte, N., Fruscione, F., Castroflorio, E., Michetti, C., Giansante, G., Valtorta, F., Tsai, J. W., Zara, F., Nieus, T., Corradi, A., Fassio, A., Baldelli, P., & Benfenati, F.

Cereb Cortex. (2019). DOI: 10.1093/cercor/bhy079

Organoids

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

(paper)

Mellough C. B., Collin J., Queen R., Hilgen G., Dorgau B., Zerti D., Felemban M., White K., Sernagor E., Lako M.

Stem Cell Translational Medicine (2019), DOI: 10.1002/sctm.18-0267

Acute Retina

Non-parametric Physiological Classification of Retinal Ganglion Cells in the Mouse Retina

(paper)

Jouty J., Hilgen G., Sernagor E. and Hennig M.H.

Front. Cell. Neurosci. (2018). DOI: https://doi.org/10.3389/fncel.2018.00481

Acute Brain Slices

High Density Multi Electrode Array: a new tool to monitor seizure-like activity evoked by different convulsant drugs

(conf. proc.)

Sessolo M., Ugolini A., Maccione A., Gandolfo M., Corsi M., Virginio C.

SFN (2018). San Diego, CA, USA.

Organoids

Development of central nervous system 3D in vitro models to study molecular mechanisms and develop therapeutic strategies for motor neuron diseases

(conf. proc.)

Faravelli I., Mapelli L., Tamanini S., Cordiglieri C., Rizzuti M., Forotti G., Bresolin N., Comi G.P., Nizzardo M., Corti S.

SFN (2018). San Diego, CA, USA.

Acute Brain Slices

Early Appearance and Spread of Fast Ripples in the Hippocampus in a Model of Cortical Traumatic Brain Injury

(paper)

Ortiz F., Karel Zapfe W.P., Draguhn A. and Gutiérrez R.

Journal of Neuroscience (2018). DOI: https://doi.org/10.1523/JNEUROSCI.3507-17.2018

Organoids

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

(paper)

Buskin, A., Zhu, L., Chichagova, V., Basu, B., Mozaffari-Jovin, S., Dolan, D., Droop, A., Collin, J., Bronstein, R., Mehrotra, S., Farkas, M., Hilgen, G., White, K., Pan, K. T., Treumann, A., Hallam, D., Bialas, K., Chung, G., Mellough, C., Ding, Y., … Lako, M.

Nat Commun 9, 4234 (2018). DOI: 10.1038/s41467-018-06448-y

Signal Processing

Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings

(paper)

Pastore V. P., Massobrio P., Godjoski A. and Martinoia S.

PLOS Computational Biology (2018). DOI: https://doi.org/10.1371/journal.pcbi.1006381

Cardiomyocyte

Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays

(paper)

Dipalo M., Melle G., Lovato L., Jacassi A., Santoro F., Caprettini V., Schirato A., Alabastri A., Garoli D., Bruno G., Tantussi F., De Angelis F.

Nature Nanotechnology (2018). DOI: https://doi.org/10.1038/s41565-018-0222-z

Technology

Exploiting All Programmable SoCs in Neural Signal Analysis: A Closed-Loop Control for Large-Scale CMOS Multielectrode Arrays

(paper)

Seu G. P., Angotzi G. N., Boi F., Raffo L., Berdondini L., and Meloni P.

IEEE Transactions on Biomedical Circuits and Systems (2018). DOI: 10.1109/TBCAS.2018.2830659

Organoids

Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency

(paper)

Hallam D., Hilgen G., Dorgau B., Zhu L., Yu M., Bojic S., Hewitt P., Schmitt M., Uteng M., Kustermann S., Steel D., Nicholds M., Thomas R., Treumann A., Porter A., Sernagor E., Armstrong L. and Lako M.

Stem Cells (2018). DOI: https://doi.org/10.1002/stem.2883

Signal Processing

Spike Train Synchrony Analysis of Neuronal Cultures

(conf. proc.)

Lama N., Hargreaves A., Stevens B. and McGinnity T.M.

International Joint Conference on Neural Networks (IJCNN) (2018). DOI: 10.1109/IJCNN.2018.8489728

Acute Brain Slices

Purkinje cells firing recorded by a high density multi-electrode array: a new tool for compounds validation

(conf. proc.)

Ugolini A., Sessolo M., Maccione A., Bettini E., Gandolfo M., Corsi M., Virginio C.

FENS conference (2018). Berlin, Germany.

Neuronal Cultures

State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures

(paper)

Nieus T., D’Andrea V., Amin H., Di Marco S., Safaai H., Maccione A., Berdondini L. and Panzeri S.

Scientific Reports (2018). DOI: 10.1038/s41598-018-23853-x

Acute Retina

Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells

(paper)

Stroh S., Puller C., Swirski S., Holzel M., van der Linde L.I.S., Segelken J., Schultz K, Block C., Monyer H., Willecke K., Weiler R., Greschner M., Janssen-Bienhold U. and Dedek K.

The Journal of Neuroscience (2018). DOI: https://doi.org/10.1523/JNEUROSCI.0141-17.2018

Technology

Fabrication of Multielectrode Arrays for Neurobiology Applications

(book chapter)

Malerba M., Amin H., Angotzi G. N., Maccione A., Berdondini L.

Cell-Based Microarrays, Methods in Molecular Biology, Editors: Ertl P., Rothbauer M., Springer (2018). DOI: https://doi.org/10.1007/978-1-4939-7792-5_12

Neuronal Cultures

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics

(paper)

Amin H., Marinaro F., De Pietri Tonelli D., Berdondini L.

Scientific Report (2017). DOI: 10.1038/s41598-017-15793-9

Signal Processing

SPICODYN: A Toolbox for the Analysis of Neuronal Network Dynamics and Connectivity from Multi-Site Spike Signal Recordings

(paper)

Pastore V. P., Godjoski A., Martinoia S., Massobrio P.

Neuroinform (2017). DOI: https://doi.org/10.1007/s12021-017-9343-z

Technology

Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks

(paper)

Lonardoni D., Hayder A., Di Marco S., Maccione A., Berdondini L., Nieus T.

PLOS, computation biology (2017). DOI: https://doi.org/10.1371/journal.pcbi.1005672

Neuronal Cultures

Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge

(paper)

Dante S., Petrelli A., Petrini E., Marotta E., Maccione A., Alabastri A., Quarta A., De Donato F., Ravasenga T., Sathya A., Cingolani R., Proietti Zaccaria R., Berdondini L., Barberis A., Pellegrino T.

ACS Nano (2017). DOI:10.1021/acsnano.7b00397

Acute Brain Slices

Polyethylene glycol restores axonal conduction after corpus callosum transection

(paper)

Bamba R., Riley D. C., Boyer R. B., Pollins A.C., Shack R.B., Thayer W.P.

Neural regeneration research (2017). DOI: 10.4103/1673-5374.206645

Neuronal Cultures

High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies

(paper)

Amin H., Nieus T., Lonardoni D., Maccione A. and Berdondini L.

Scientific Reports (2017). DOI: 10.1038/s41598-017-02635-x

Signal Processing

Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays

(paper)

Hilgen G., Sorbaro M, Pirmoradian S, Muthmann J-O., Kepiro I, Ullo S., Rmairez C. J., Encinas A. P., Maccione A., Berdondini L., Murino V., Sona D., Cella Zanacchi F., Sernagor E., Hennig M.

Cell Reports (2017). DOI: http://dx.doi.org/10.1016/j.celrep.2017.02.038

Acute Retina

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

(paper)

Hilgen G., Pirmoradian S., Pamplona D., Kornprobst P., Cessac B., Hennig M., Sernagor E.

Sci Rep. (2017). DOI: 10.1038/srep42330

Acute Brain Slices

Exploiting high content datasets recorded with high density Multi Electrode Array to investigate compounds functional effects with LTP protocols in cortico-hippocampal brain slices

(conf. proc.)

Zordan S., Ugolini A., Virginio C., Corsi M., Lonardoni D., Gandolfo M., Maccione A. and Berdondini L.

SFN conference (2016). San Diego, CA, USA.

Acute Retina

Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses

(paper)

Barrett J. M., Hilgen G. and Sernagor E.

Sci Rep. (2016). DOI: 10.1038/srep33565

Technology

Specific Neuron Placement on Gold and Silicon Nitride-Patterned Substrates through a Two-Step Functionalization Method

(paper)

Mescola A., Canale C., Prato M., Diaspro A., Berdondini L., Maccione A., and Dante S.

Langmuir (2016). DOI: 10.1021/acs.langmuir.6b01352.

Acute Retina

Rank order coding: a retinal information decoding strategy revealed by large-scale multielectrode array retinal recordings.

(paper)

Portelli G., Barrett J.M., Hilgen G., Masquelier T., Maccione A., Di Marco S., Berdondini L., Kornprobst P., Sernagor E.

ENeuro (2016). DOI: 10.1523/ENEURO.0134-15.2016.

Neuronal Cultures

Electrical responses and spontaneous activity of human iPS-derived neuronal networks characterized for three-month culture with 4096-electrode arrays

(paper)

Amin H., Maccione A., Marinaro F., Zordan S., Nieus T., Berdondini L.

Front. Neurosci. (2016). DOI: 10.3389/fnins.2016.00121.

Signal Processing

ToolConnect: a functional connectivity toolbox for in vitro networks

(paper)

Pastore V. P., Poli D., Godjoski A., Martinoia S., Massobrio P.

Frontiers in Neuroinformatics (2016). DOI: 10.3389/fninf.2016.00013

Neuronal Cultures

State-Dependent Propagation of Neuronal Sub-Population in Spontaneous Synchronized Bursts

(paper)

Yuichiro Y., Ryohei K. and Hirokazu T.

Front. Syst. Neurosci. (2016). DOI: 10.3389/fnsys.2016.00028.

Neuronal Cultures

Propagation and synchronization of reverberatory bursts in developing cultured networks

(paper)

Huang CH., Huang YT., Chen CC., Chan CK.

J Comput Neurosci (2016). DOI: 10.1007/s10827-016-0634-4.

Signal Processing

Spike detection for large neural populations using high density multielectrode arrays

(paper)

Muthmann O., Amin H., Sernagor E., Maccione A., Panas D., Berdondini L., Bhalla U. S., Hennig M.

Frontiers in Neuroinformatics (2015). ISSN:1662-5196 DOI:10.3389/fninf.2015.00028

Neuronal Cultures

High-density MEA recordings unveil the dynamics of bursting events in Cell Cultures

(conf. proc.)

Lonardoni D., Di Marco S., Amin H., Maccione A., Berdondini L., Nieus T.

Engineering in Medicine and Biology Society - 37th Annual International Conference of the IEEE (2015). DOI: 10.1109/EMBC.2015.7319212.