From dissociated cultures to human iPSC-derived neurons, explore new pathways in drug discovery and brain research
Dissociated cultures grown on our high density Microelectrode Arrays are used to investigate fundamental properties of brain processing, to study the physiological and pathological functional activity of cultured models on primary or derived cell-lines, and for developing drug-screening or toxicological applications.
The high resolution technology of BioCAM X can foster your R&D on neuronal networks by enabling you to:
Our high density Multielectrode Array is the ideal tool in pre-clinical toxicological/pharmacological screenings to assess in vitro models of severe long term neurodegenerative diseases, such as Alzheimer's and Parkinson's.
Thanks to the high number of recording sites, functional alteration caused by insulting agents, such as Aβ oligomers, or the rescue effects of neuroprotective compounds, can be evaluated in label-free assays with unprecedented statistical significance and with a sensitivity superior to most common cellular death assays or imaging techniques as demonstrated for instance in Amin et al., Sci Reports 2017.
Human induced pluripotent stem cell-derived neuronal networks are the most promising tools to improve understanding of brain disease by in-vitro modelling. Our high density Multielectrode Arrays are the first CMOS-based devices fully validated with human-derived neurons. Spontaneous, as well as electrically-evoked, activity has been monitored for more than three months over different adhesion coatings. See more
Combined with optical imaging, it provides a powerful tool to investigate the relationship between function and structure in cultures. See more