Brain tissues & safety/toxicology

Functional imaging of large portions of tissue to study circuitry and mechanisms of compounds

Overview

Brain tissues

Our high density Multi Electrode Array can visualize both spiking activity and field potential propagations (fEPSP, Population Spikes) over large brain circuits in acute brain tissue preparations at unprecedented spatial and temporal resolutions, enabling you to:

  • Monitor spontaneous activity patterns over large brain regions
  • Map chemically/electrically induced activity propagations over multiple circuits. See more
  • Apply plasticity protocols and reliably assess induced changes . See more
Fast ripples detected in the hippocampus and DG. Adapted from F. Ortiz, R. Gutiérrez, SfN 2016 (poster).  See more
Fast ripples propagating in a disorganized manner. Adapted from F. Ortiz, R. Gutiérrez, SfN 2016 (poster)  See more

Safety, toxicology and mechanism of action

Our high density Multielectrode Array allows the user to study circuitry and neuronal assembly communication in label-free mode, at a micro-scale level and over large regions. See more videos

This is of great interest to those seeking an understanding of the potential targets of molecules, for example in the field of epilepsy. See more


Functional images of an inter-ictal event propagating from the Dentate Gyrus to the Perirhinal Cortex. The false-coloured electrophysiological activity recorded by the HD-MEA has been superimposed onto the image of the slice. Adapted from Ferrea et al., Front. Neural Circuits 2012. See more

LTP on the CA1 dendritic region induced by High Frequency Stimulation (HFS) delivered in the CA3 area. Upper row: field EPSP (left) is potentiated after HFS (right). Lower row: no potentiation occurs when the slice is perfused with D-AP5. The HD-MEA's (link) large sensing area (array's grid on the back) allows the whole effect in the areas of interest to be appreciated. Courtesy of Aptuit Verona, Italy.

Long Term Potentiation/Depression

LTP/LTD experimental protocols are routinely used in evaluating memory deficit induced by potentially neurotoxic compounds. Our high density Multi Electrode Array allows superior performance in such experiments, thanks to the capability to monitor the entire area of interest with high statistical significance and to investigate heterogeneous compound effects in smaller brain regions.


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