BioCAM X

Large-scale sensing Microelectrode Array platform for label-free in-vitro electrophysiology


BioCam X is the most advanced MEA platform for in-vitro electrophysiology.

4096 electrodes sampled at 18kHz to boost your research and to image neuronal network complexity. 




Overview

Small footprint, large yields

We have combined high technology, materials and functional design to achieve an outstanding compact device that has no parallel in the market. 

4096 recording electrodes, sampled simultaneously at 18kHz, provide orders of magnitude more data points compared to conventional passive Multielectrode Arrays (MEAs),

thus leading to the recording, over a large bandwidth, of electrophysiological signals ranging from slow large-population field potentials to fast single-cell spiking activity.

The BioCAM X platform delivers unique insights into several in-vitro electrophysiological models, such as neuronal cell cultures, brain slices, retina preparations and cardiac cultures.

All-in-one

BioCAM X incorporates further optional functionalities, which come as separate modules in most MEA-systems, such as a temperature control system and an electrical programmable current-driven stimulator.

A compact MEA platform

BioCAM X's small footprint allows easy integration with lab equipment commonly used in electrophysiology, such as microscopes, and perfusion and patch-clamp systems.

"Plug-and-record" quick system

BioCAM X has the easiest mechanical system for plugging in MEA chips. Just one click to lock the chip and to start immediately to visualize and record your data on the BrainWave's visual interface. Unlocking it is just as easy.

Unique feature

Anti-Spill barrier

When the HD-MEA probe is inserted and locked into its bay, a barrier comes down separating the downstream electronics. This prevents circuitry damage in case of accidental overflow of liquids.

ACCESSORIES

Expand your experimental capabilities

We provide a series of accessories which enable users to get the best from the BioCAM X platform, such as an integrated stimulus generator. Find out more

CONSUMABLES
MEA probes

CMOS HD-MEA

CMOS-based high density multielectrode arrays (HD-MEAs) are multi-use devices with 4096 recording electrodes for high resolution in-vitro extracellular electrophysiology. The chip is based on CMOS technology and is packaged onto a substrate together with a glass reservoir.

Different models for different needs are available. See more

HD-MEA electrodes are coated with Pt to provide a stable and fully biocompatible surface. The quality of the recording is ensured by the impressive signal-to-noise ratio, as you can appreciate from our video samples section. See videos

Software

BrainWave X

BioCAM X is supplied with the latest BrainWave X software version, which provides powerful visualization and analysis tools for electrophysiological signals during and after your experiments and stores all your data in HDF5 format.

RESOURCES

Here you can find useful resources for your BioCAM X


Download Brochure            Download User Guide

Tech specs

Amplifier

bandwidth 0.1 Hz - 20 kHz
noise 11 µVrms (0.1 Hz - 20 kHz)
maximum input-referred signal amplitude 4 mV

Main Controller

data resolution 12 bit
# of simultaneous recording sites 4096
full-array (4096) maximum sampling rate 18 kHz / electrode
region-of-interests recording 1 up to 4 independent subsets of electrodes up to 64 kHz
temperature control active heating and cooling between 34°C and 40°C
inputs two analog inputs (-3.3 V to 3.3 V) or triggers (LV-TTL)
control interface Camera Link (mini SDR)

Stimulation Module optional

stimulation mode constant current
internal stimulation sites 16 on-chip (only for HD-MEA Stimulo)
external stimulation sites 4 differential channels accessible on the rear connector
maximum current
+/- 1 mA
stimulation patterns
up to 4 independent stimulation patterns
stimulus generator
programmable patterns (mono/biphasic, burst, jittering,...)
time resolution
10 μs
amplitude resolution
10 μA
maximum pulse rate
50 kHz
extended inputs
three LV-TTL GPIOs

Software

OS Windows Vista / 7 / 8 / 10, 64 bit
data processing fully parallelized; AVX2 instruction set
file type BRW (raw data) and BXR (results file) with plain HDF5 format
online recording modes
BRW: plain raw, lossless zipped raw, lossy raw. BXR: events’ timestamps
data export
MAT (Matlab); NEX (Neuroexplorer)

Phisical Specs

body material anodized aluminum and stainless steel
dimensions (WxDxH) 160 x 205 x 38 mm / 6.3 x 8.07 x 1.5 inches
weight approx. 1350 g / 2.98 lb